CLINICAL CASE
Honey allergy in adult allergy practice
G. Karakaya and A. Fuat Kalyoncu
Hacettepe University Hospital. Department of Chest Diseases. Adult Allergy Unit. Ankara. Turkey.
Correspondence:
Gül Karakaya, MD
Hacettepe University Hospital
Department of Chest Diseases
Adult Allergy Unit
06100 Sihhiye Ankara.
Turkey
SUMMARY
Honey allergy is a very rare condition which shows a clinical picture ranging from cough to anaphylaxis after ingestion of honey. Here we report 5 cases of honey allergy.
Key words: Honey allergy. Cough. Anaphylaxis.
RESUMEN
La alergia a la miel es muy poco frecuente, presenta un cuadro clínico con síntomas que van desde tos a anafilaxis tras la ingestión de miel. En este artículo aportamos cinco casos de alergia a la miel.
Palabras clave: Alergia a la miel. Tos. Anafilaxis.
INTRODUCTION
Food allergy due to honey is very rare (1, 2). In a study performed on 4,331 students none of them had honey allergy (3). Ingested honey can cause reactions varying from cough to anaphylaxis (1, 2, 4, 5). It usually appears in people with seasonal rhinoconjunctivitis having pollen allergy. The most common reasons are the pollens and/or the bee body components including the bee venom in the honey (5). Although some serum and oral provocation tests having been performed, there are not any standard tests for the diagnosis. Most of the reported cases are related with IgE mediated allergy, but there are also some non-allergic cases in the literature with honey hypersensitivity or intolerance (6). Here we report cases who had reactions after ingestion of honey, were only one of them was pollen allergic.
CASES
Case 1
A 68-year-old housewife born in a city in western Turkey and has been still living there. She complained of having abdominal pain after eating honey since her childhood. In the last 2 years her abdominal pain is more severe and she has had acute urticaria attacks in addition to this. She was able to eat forest honey but not flower honey, but recently forest honey also produced reactions. When she uses detergents, make-up material and beauty creams she experiences generalized urticaria and angioedema. She also has had eczema in her hands after using detergents. She complained of generalized itching after eating spicy food and nuts. Skin prick tests were not performed due to her dermographism. Total serum IgE value was 7.1 kU/L, which is within normal limits and phadiatop was negative. Specific serum IgE for honey was negative (
Case 2
A 46-year-old housewife complained of having acute urticaria and nasal discharge after eating coconut, vanilla and honey several times. Skin prick tets with common aeroallergens and with food were negative. She is a smoker and her father had asthma. Her serum total IgE value was within the normal range (34.9 kU/L) and Phadiatop was negative, Specific serum IgE levels for coconut, vanilla and honey were all negative (
Case 3
A 63-year-old retired government officer who had been diagnosed small cell lung cancer and had received two cycles of chemotherapy consisted of cisplatine-etoposide had been referred by the medical oncologists for his recurrent generalized urticaria and angioedema attacks. They had wanted to know if these could be due to the chemotherapeutic agents. The patient has mentioned that he had been having honey and royal gelly with the purpose of paramedical support since the beginning of his cancer and he had realized that reactions had been appearing after having these in the last 3 times. All of the tests performed to find out the etiology of urticaria and angioedema were normal. His skin prick tests with aeroallergens and food were negative. His total serum IgE level was normal (46.2 kU/L): After stopping having honey and royal gelly, the patient has recovered and the oncologists could complete the chemotherapy to 6 cycles.
Case 4
A 50-year-old man who is a teacher, has had seasonal rhinoconjunctivitis for 6 years. He has had acute angioedema after tasting honey 3 times in the last 4 years. He was exposed to honey bee stings 5-6 times since his childhood and he had acute urticaria and angioedema each time. The routine skin prick test with common aeroallergens was positive for phleum pratense. Prick tests with food and apis mellifera and vespula species were all negative. His total serum IgE level was within the normal range (21.4 kU/L).
Case 5
A 60-year-old male patient, who is a lawyer has had chronic diarrhea for 25 years and no disease explaining this diarrhea has been found for years in various gastroenterology clinics. Sweet food increased the severity of his diarrhea. He had acute urticaria with honey 4-5 times 5 years ago.La prueba de punción cutánea con aeroalergenos comunes y con alimentos fue negativa. El nivel sérico total de IgE se encontraba dentro del rango normal (12,7 kU / L).
DISCUSIÓN
Entre enero de 1991 y septiembre de 1998, se han realizado 3.810 primeras derivaciones al Departamento de Enfermedades Torácicas. , Unidad de Alergias para Adultos de la Universidad de Hacettepe y solo hubo 7 pacientes alérgicos a la miel (% 0.2) donde 2 de ellos habían informado antes (7). Entre estos, 448 de ellos tenían rinoconjuntivitis estacional (RS) de los cuales 3 tenían alergia a la miel (0,7%). Entre nuestros pacientes alérgicos / intolerantes a la miel, 4 de ellos no tenían SR y tenían resultados negativos en la prueba de punción cutánea, los niveles séricos de IgE total estaban dentro del rango normal en todos, ninguno de ellos tuvo reacciones potencialmente mortales, todos tenían más de mediana edad , todos conocían la relación entre las reacciones y la miel antes de la remisión y todos habían experimentado las reacciones varias veces, por lo que no hubo necesidad de pruebas de provocación oral. Como resultado, la alergia a la miel no es solo un problema mediado por IgE que se observa en personas alérgicas al polen, sino que también puede causar reacciones de hipersensibilidad en personas no atópicas. De todos modos, se puede aceptar que las reacciones que aparecen en estos pacientes no son potencialmente mortales.
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